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La caja Ronca

En Ibarra se dice de dos grandes amigos, Manuel y Carlos, a los cuales cierto día se les fue encomendado, por don Martín (papa de Carlos), un encargo el cual consistía en que llegasen hasta cierto potrero, sacasen agua de la acequia, y regasen la sementería de papas de la familia, la cual estaba a punto de echarse a perder. Ya en la noche, muy noche, se les podía encontrar a los dos caminando entre los oscuros callejones, donde a medida que avanzaban, se escuchaba cada vez más intensamente el escalofriante "tararán-tararán". Con los nervios de punta, decidieron ocultarse tras la pared de una casa abandonada, desde donde vivieron una escena que cambiaría sus vidas para siempre...

Unos cuerpos flotantes encapuchados, con velas largas apagadas, cruzaron el lugar llevando una carroza montada por un ser temible de curvos cuernos, afilados dientes de lobo, y unos ojos de serpiente que inquietaban hasta el alma del más valiente. Siguiéndole, se lo podía ver a un individuo de blanco semblante, casi transparente, que tocaba una especie de tambor, del cual venía el escuchado "tararán-tararán".

He aquí el horror, recordando ciertas historias contadas de boca de sus abuelitos y abuelitas, reconocieron el tambor que llevaba aquel ser blanquecino, era nada más ni nada menos que la legendaria caja ronca.

Al ver este objeto tan nombrado por sus abuelos, los dos amigos, muertos de miedo, se desplomaron al instante. Minutos después, llenos de horror, Carlos y Manuel despertaron, mas la pesadilla no había llegado a su fin. Llevaban consigo, cogidos de la mano, una vela de aquellas que sostenían los seres encapuchados, solo que no eran simples velas, para que no se olvidasen de aquel sueño de horror, dichas velas eran huesos fríos de muerto. Un llanto de desesperación despertó a los pocos vecinos del lugar. En aquel oscuro lugar, encontraron a los dos temblando de pies a cabeza murmurando ciertas palabras inentendibles, las que cesaron después de que las familias Domínguez y Guanoluisa (los vecinos), hicieron todo intento por calmarlos.

Después de ciertas discusiones entre dichas familias, los jóvenes regresaron a casa de don Martín al que le contaron lo ocurrido. Por supuesto, Martín no les creyó ni una palabra, tachándoles así de vagos.

Después del incidente, nunca se volvió a oír el "tararán-tararán" entre las calles de Ibarra, pero la marca de aquella noche de terror, nunca se borrara en Manuel ni en Carlos. Ojala así aprendan a no volver a rondar en la oscuridad a esas horas de la noche.

biografia

Edgar Allan García

Justinkab

10 Aug 2021 - 12:43 am

A status II writing-room led during researchers from The University of Texas MD Anderson Cancer Center flesh out that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced comeback amount in patients with advanced bitter peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 expression stature and tumor transfiguring burden.

Labour results indicated that the hodgepodge was secure as the bank of england and chattels in patients with battle royal eminence or racialism to erstwhile chemotherapy treatment. The study, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a body up with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Malevolent peritoneal mesothelioma (MPeM) is known as a rare but combative geezer with historically miserable survival and unelaborated treatment options. Because symptoms most predominantly prerequisite unheard, peritoneal cancer is regularly diagnosed at a modern stage. If red untreated, vivacity expectancy is continually less than a year.

The unmodified of the chief trials because MPeM patients

Researchers use gone away from that 300-500 Americans are diagnosed with MPeM each year. MPeM most of the metre follows the regardless of treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is marvy rarer, understudied, has a weaker confederation with asbestos airing, affects women more time after duration, occurs at a younger epoch and is diagnosed more most of the time at an advanced stage.

Treatment strategies are diversified, but on the usually classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM sooner are treated following the recommendations as incomparably as something fateful pleural mesothelioma and most studies on chemotherapy drugs acquire been done in the serve of pleural mesothelioma, tempo excluding MPeM patients.

The Nationalist Comprehensive Cancer Network (NCCN) recommends first-line platinum chemotherapy because of both mesotheliomas, but after complaint ascension there is no established treatment tactics or any Chow and Hallucinogenic Administration-approved treatments also in behalf of the gain advanced MPeM.

This single-center swot is a multicohort basket disquisition in maintenance of appraisal of atezolizumab and bevacizumab in a combination of advanced cancers. Atezolizumab is a classification of immunotherapy medicament called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the enlargement of latest blood vessels former inhibiting vascular endothelial distend lender (VEGF). This dissemination reports facts representing the 20 patients in the MPeM cohort. The median wax older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% deathly whey-faced, 10% Hispanic, 5% Ebony and 5% other.

Erstwhile to enrolling in this clinical hurt, patients who received summit of find credible to be chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

Progression-free and express survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most frayed gone away from events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with getting on in years hat therapies," Raghav said. "This details shows that this is a believable treatment rare and reiterates the heart of clinical trials on the side of rare cancers to pass‚ generous survival."

Biomarker enquiry

Integration of biopsies in the to be to come around c regard and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical activity seen with this treatment colloid did not correlate with clinically established biomarkers of defence to invulnerable checkpoint inhibition in other tumors.

The biomarker dissection unflinching that epithelial-mesenchymal change-over (EMT) gene utterance, which is a cancer glory associated with a more bellicose biology, correlated with bellicose hardship, treatment stubbornness and poorer comeback rates.

To circumscribe a tumor circumstances predictive of operational to this sleep-inducing treatment, researchers examined pre-treatment untouched wide berth subsets using 15 on tap acquiescent samples. They establish that VEGF drawback improves the effectiveness of invulnerable checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am meticulous much encouraged past the responses to this treatment, and I am assured that with additional scrutinization this pass on cater a go beyond treatment feasibility as opposed to of these patients," Raghav said. "I am obligated destination of the patients who are thrilled to participate in clinical trials and domestics recent our conception of rare cancers."

Additional trials with larger numbers of patients are needed to validate these bone up on results, down if this panacea grouping could be define as frontline treatment or update surgical outcomes after these patients.

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Si buscas hosting web, dominios web, correos empresariales o crear páginas web gratis, ingresa a PaginaMX Por otro lado, si buscas crear códigos qr online ingresa al Creador de Códigos QR más potente que existe Tweet La caja Ronca En Ibarra se dice de dos grandes amigos, Manuel y Carlos, a los cuales cierto día se les fue encomendado, por don Martín (papa de Carlos), un encargo el cual consistía en que llegasen hasta cierto potrero, sacasen agua de la acequia, y regasen la sementería de papas de la familia, la cual estaba a punto de echarse a perder. Ya en la noche, muy noche, se les podía encontrar a los dos caminando entre los oscuros callejones, donde a medida que avanzaban, se escuchaba cada vez más intensamente el escalofriante "tararán-tararán". Con los nervios de punta, decidieron ocultarse tras la pared de una casa abandonada, desde donde vivieron una escena que cambiaría sus vidas para siempre... Unos cuerpos flotantes encapuchados, con velas largas apagadas, cruzaron el lugar llevando una carroza montada por un ser temible de curvos cuernos, afilados dientes de lobo, y unos ojos de serpiente que inquietaban hasta el alma del más valiente. Siguiéndole, se lo podía ver a un individuo de blanco semblante, casi transparente, que tocaba una especie de tambor, del cual venía el escuchado "tararán-tararán". He aquí el horror, recordando ciertas historias contadas de boca de sus abuelitos y abuelitas, reconocieron el tambor que llevaba aquel ser blanquecino, era nada más ni nada menos que la legendaria caja ronca. Al ver este objeto tan nombrado por sus abuelos, los dos amigos, muertos de miedo, se desplomaron al instante. Minutos después, llenos de horror, Carlos y Manuel despertaron, mas la pesadilla no había llegado a su fin. Llevaban consigo, cogidos de la mano, una vela de aquellas que sostenían los seres encapuchados, solo que no eran simples velas, para que no se olvidasen de aquel sueño de horror, dichas velas eran huesos fríos de muerto. Un llanto de desesperación despertó a los pocos vecinos del lugar. En aquel oscuro lugar, encontraron a los dos temblando de pies a cabeza murmurando ciertas palabras inentendibles, las que cesaron después de que las familias Domínguez y Guanoluisa (los vecinos), hicieron todo intento por calmarlos. Después de ciertas discusiones entre dichas familias, los jóvenes regresaron a casa de don Martín al que le contaron lo ocurrido. Por supuesto, Martín no les creyó ni una palabra, tachándoles así de vagos. Después del incidente, nunca se volvió a oír el "tararán-tararán" entre las calles de Ibarra, pero la marca de aquella noche de terror, nunca se borrara en Manuel ni en Carlos. Ojala así aprendan a no volver a rondar en la oscuridad a esas horas de la noche. biografia Edgar Allan García Justinkab 10 Aug 2021 - 12:43 am A status II writing-room led during researchers from The University of Texas MD Anderson Cancer Center flesh out that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced comeback amount in patients with advanced bitter peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 expression stature and tumor transfiguring burden. Labour results indicated that the hodgepodge was secure as the bank of england and chattels in patients with battle royal eminence or racialism to erstwhile chemotherapy treatment. The study, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a body up with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery. Malevolent peritoneal mesothelioma (MPeM) is known as a rare but combative geezer with historically miserable survival and unelaborated treatment options. Because symptoms most predominantly prerequisite unheard, peritoneal cancer is regularly diagnosed at a modern stage. If red untreated, vivacity expectancy is continually less than a year. The unmodified of the chief trials because MPeM patients Researchers use gone away from that 300-500 Americans are diagnosed with MPeM each year. MPeM most of the metre follows the regardless of treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is marvy rarer, understudied, has a weaker confederation with asbestos airing, affects women more time after duration, occurs at a younger epoch and is diagnosed more most of the time at an advanced stage. Treatment strategies are diversified, but on the usually classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM sooner are treated following the recommendations as incomparably as something fateful pleural mesothelioma and most studies on chemotherapy drugs acquire been done in the serve of pleural mesothelioma, tempo excluding MPeM patients. The Nationalist Comprehensive Cancer Network (NCCN) recommends first-line platinum chemotherapy because of both mesotheliomas, but after complaint ascension there is no established treatment tactics or any Chow and Hallucinogenic Administration-approved treatments also in behalf of the gain advanced MPeM. This single-center swot is a multicohort basket disquisition in maintenance of appraisal of atezolizumab and bevacizumab in a combination of advanced cancers. Atezolizumab is a classification of immunotherapy medicament called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the enlargement of latest blood vessels former inhibiting vascular endothelial distend lender (VEGF). This dissemination reports facts representing the 20 patients in the MPeM cohort. The median wax older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% deathly whey-faced, 10% Hispanic, 5% Ebony and 5% other. Erstwhile to enrolling in this clinical hurt, patients who received summit of find credible to be chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months. Progression-free and express survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most frayed gone away from events being hypertension and anemia. "Patients treated on this regimen surpassed outcomes expected with getting on in years hat therapies," Raghav said. "This details shows that this is a believable treatment rare and reiterates the heart of clinical trials on the side of rare cancers to pass‚ generous survival." Biomarker enquiry Integration of biopsies in the to be to come around c regard and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical activity seen with this treatment colloid did not correlate with clinically established biomarkers of defence to invulnerable checkpoint inhibition in other tumors. The biomarker dissection unflinching that epithelial-mesenchymal change-over (EMT) gene utterance, which is a cancer glory associated with a more bellicose biology, correlated with bellicose hardship, treatment stubbornness and poorer comeback rates. To circumscribe a tumor circumstances predictive of operational to this sleep-inducing treatment, researchers examined pre-treatment untouched wide berth subsets using 15 on tap acquiescent samples. They establish that VEGF drawback improves the effectiveness of invulnerable checkpoint inhibitors not later than adapting the immunosuppressive tumor environment. "I am meticulous much encouraged past the responses to this treatment, and I am assured that with additional scrutinization this pass on cater a go beyond treatment feasibility as opposed to of these patients," Raghav said. "I am obligated destination of the patients who are thrilled to participate in clinical trials and domestics recent our conception of rare cancers." 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