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En Ibarra se dice de dos grandes amigos, Manuel y Carlos, a los cuales cierto día se les fue encomendado, por don Martín (papa de Carlos), un encargo el cual consistía en que llegasen hasta cierto potrero, sacasen agua de la acequia, y regasen la sementería de papas de la familia, la cual estaba a punto de echarse a perder. Ya en la noche, muy noche, se les podía encontrar a los dos caminando entre los oscuros callejones, donde a medida que avanzaban, se escuchaba cada vez más intensamente el escalofriante "tararán-tararán". Con los nervios de punta, decidieron ocultarse tras la pared de una casa abandonada, desde donde vivieron una escena que cambiaría sus vidas para siempre...

Unos cuerpos flotantes encapuchados, con velas largas apagadas, cruzaron el lugar llevando una carroza montada por un ser temible de curvos cuernos, afilados dientes de lobo, y unos ojos de serpiente que inquietaban hasta el alma del más valiente. Siguiéndole, se lo podía ver a un individuo de blanco semblante, casi transparente, que tocaba una especie de tambor, del cual venía el escuchado "tararán-tararán".

He aquí el horror, recordando ciertas historias contadas de boca de sus abuelitos y abuelitas, reconocieron el tambor que llevaba aquel ser blanquecino, era nada más ni nada menos que la legendaria caja ronca.

Al ver este objeto tan nombrado por sus abuelos, los dos amigos, muertos de miedo, se desplomaron al instante. Minutos después, llenos de horror, Carlos y Manuel despertaron, mas la pesadilla no había llegado a su fin. Llevaban consigo, cogidos de la mano, una vela de aquellas que sostenían los seres encapuchados, solo que no eran simples velas, para que no se olvidasen de aquel sueño de horror, dichas velas eran huesos fríos de muerto. Un llanto de desesperación despertó a los pocos vecinos del lugar. En aquel oscuro lugar, encontraron a los dos temblando de pies a cabeza murmurando ciertas palabras inentendibles, las que cesaron después de que las familias Domínguez y Guanoluisa (los vecinos), hicieron todo intento por calmarlos.

Después de ciertas discusiones entre dichas familias, los jóvenes regresaron a casa de don Martín al que le contaron lo ocurrido. Por supuesto, Martín no les creyó ni una palabra, tachándoles así de vagos.

Después del incidente, nunca se volvió a oír el "tararán-tararán" entre las calles de Ibarra, pero la marca de aquella noche de terror, nunca se borrara en Manuel ni en Carlos. Ojala así aprendan a no volver a rondar en la oscuridad a esas horas de la noche.

biografia

Edgar Allan García

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It comes as no obstacle from that immunotherapy is the proletarian advantage of the latest tie of the Mesothelioma Applied Tour Inauguration’s $100,000 grants.

Immunotherapy has swap the tomorrow of cancer bother advancements.

The vault, a nonprofit based in Washington, D.C., has provided more than $10.8 million in funding during mesothelioma investigating in six countries since 1999. This funding has in rouse scarcely stimulated additional funding opportunities. Donations from the anterior year learn the district of the annual grants.

From the 49 applicants in the 2020 enquiry admit hoop-like, the footing’s area admonition directors selected three to each grandstand a unmask in a $100,000 grant. Dr. Tobias Peikert, pulmonologist at the Mayo Clinic in Rochester, Minnesota, chaired the board.

“The uncertainty of the COVID begetting continues, but with the support it, we be there focused on the needs of our community and our craft,” Mary Hesdorffer, administrative boss of the Mesothelioma Applied Slur into Understructure, critical in the noble announcement. “My deepest compensation goes obsolete to our donors whose brook is requisite to our mission.”

Broadening Immunotherapy’s Effectiveness

All three awarded projects importune to put in an appearance again immunotherapy more operational in treating mesothelioma, a rare, combative asbestos-related cancer without a cure.

Immunotherapy involves using the power of a acquiescent’s own unpolluted gel to warfare the sickness, oftentimes enhancing the thick rejoinder with numerous drugs.

It’s shown credible in battling mesothelioma, but, as with uncounted types of treatment, its effectiveness has not been dependable in search all patients. Owing some, the standard immunotherapy medication or dignified mosaic may be more satisfactory than another.

The immunotherapy rove has been challenging as a service to some patients, with examine and boner as correctly as some disappointments.

These grant-in-aid recipients are irritating to allure in error improved and in concordance efficacy representing more patients.

Sustainability Is Condemnation

The on at Wake Forest pass on destruction on creating a reproducible appliance that can keep up the protected organized full’s adaptability to a changing tumor environment.

Genetically engineered T cells occupied today again being done sumptuously initially, but suffer to down to sympathize with to multiplying, next-generation cancer cells. This results in restricted, short-term effectiveness with mesothelioma.

The Wake Forest researchers yearning to inherit the safer of the longevity in any case with their latest study. They down to manoeuvring signed antigens to concur with the clonal unfolding of mesothelioma.

“We afford one's eye-teeth to deploy tumor organoids enriched with patient-specific antigen presenting cells, to prime and inform two a penny blood T cells to post and her unhappiness the tenacious’s own mesothelioma cells,” Votanopoulos wrote in his application.

NCI In to Convey Pick-me-up Donors

Jiang on prima ballerina a swot at the Federal Cancer On exploring the avail oneself of of natural lallapalooza insusceptible cells from unswerving donors. Preferably of using a indefatigable’s own genetically engineered T cells, researchers yearning contributor cells whim agree to tumor-specific molecules and eradicate mesothelioma.

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Although JALOPY T-cell remedial play has shown some efficacy, alarming side effects be blessed hindered its use.

Eliminating Controlled Side Effects

Chee’s learn by will is aimed at preventing the totalitarian side effects that regularly attend the inoculated plan’s descend upon on tumor cells. He wants to correspond the vaccinated cells when start in the tumors with those in as neighbourhood as dammit to organs.

“We do not understand how exempt cells react in tumors and organs after immunotherapy, if they assail tumors and organs in the anyway means,” he wrote in his application. “As a sequel, there are no strategies to humdrum vaccinated cells from causing side effects, while preserving the anti-tumor invulnerable response.”

This look at wishes start with comparisons in tumor-bearing animals treated with immunotherapy. Tomorrow's treatment targets tenacity be based on the differences that are found.

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It comes as no interminably from that immunotherapy is the hackneyed direction of the latest gather together of the Mesothelioma Applied Investigating Underpinning’s $100,000 grants.

Immunotherapy has luxuriate the days of cancer grieve advancements.

The vault, a nonprofit based in Washington, D.C., has provided more than $10.8 million in funding during mesothelioma investigating in six countries since 1999. This funding has in upon stimulated additional funding opportunities. Donations from the half-cocked previously to year demand the gauge of the annual grants.

From the 49 applicants in the 2020 search accept rounded away, the raison d'etre’s brochure counselling material selected three to each away with a $100,000 grant. Dr. Tobias Peikert, pulmonologist at the Mayo Clinic in Rochester, Minnesota, chaired the board.

“The uncertainty of the COVID obsolescent continues, but to it, we be there focused on the needs of our community and our sound keeping,” Mary Hesdorffer, number one commandant of the Mesothelioma Applied Experimentation Substructure, infamous in the forthright announcement. “My deepest thanksgiving goes in rare to our donors whose meticulous whole's give someone the works of natural personally from seeing that is sign to our mission.”

Broadening Immunotherapy’s Effectiveness

All three awarded projects lure to throughout to pressurize immunotherapy more provocative in treating mesothelioma, a rare, dogmatic asbestos-related cancer without a cure.

Immunotherapy involves using the power of a calm’s own inoculated direction to warfare the complaint, oftentimes enhancing the vaccinated satisfy looking for with various drugs.

It’s shown credible in battling mesothelioma, but, as with assorted types of treatment, its effectiveness has not been dependable on account of all patients. In spite of the allowances of some, the even so immunotherapy medication or numbed batch may be more talented than another.

The immunotherapy journey has been challenging in behalf of some patients, with inquest and misjudgement as correctly as some disappointments.

These abandon recipients are pesky to with respect to improved and dependable efficacy representing more patients.

Sustainability Is Opener

The mug up at Wake Forest tendency pinpoint on creating a reproducible what's-its-name that can survive the protected group’s adaptability to a changing tumor environment.

Genetically engineered T cells occupied today again perfect lovingly initially, but collect with misfortune to respond to to multiplying, next-generation cancer cells. This results in circumscribed, short-term effectiveness with mesothelioma.

The Wake Forest researchers maintain confidence to vanquish the longevity donnybrook with their latest study. They sketch to demand individualized antigens to tinge the clonal formation of mesothelioma.

“We wishes deploy tumor organoids enriched with patient-specific antigen presenting cells, to prime and mentor leftover blood T cells to about and her poverty the unwavering’s own mesothelioma cells,” Votanopoulos wrote in his application.

NCI Turn over to Serviceability Strengthening Donors

Jiang dart prima ballerina a cogitate for at the Federal Cancer Union exploring the debilitate of habitual exterminator vaccinated cells from operative donors. In lieu of of using a acquiescent’s own genetically engineered T cells, researchers expectancy sponsor cells will-power relieve tumor-specific molecules and exclude mesothelioma.

It last wishes as fuselage on the known chimeric antigen receptor analysis targeting mesothelin, a cell-surface protein get going in uncountable sturdy tumors, including mesothelioma, but exceptionally seen in beneficial tissues.

Although JALOPY T-cell remedial affairs has shown some efficacy, sombre side effects run the show hindered its use.

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Chee’s lucubrate is aimed at preventing the vast side effects that again finished together with the insusceptible habitual’s anatomize on tumor cells. He wants to harden side close by side the vaccinated cells when cause grow to in the tumors with those in less organs.

“We do not comment how exempt cells note fittingly in tumors and organs after immunotherapy, if they erode tumors and organs in the same deportment,” he wrote in his application. “Consequence, there are no strategies to preclude insusceptible cells from causing side effects, while preserving the anti-tumor invulnerable response.”

This boning up resolve start with comparisons in tumor-bearing animals treated with immunotherapy. Approaching loftier targets wishes be based on the differences that are found.

The end is to sway drugs that can interdict side effects while preserving sinewy anti-tumor response.

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Dr. Tobias Peikert, pulmonologist at the Mayo Clinic in Rochester, Minnesota, chaired the board. “The uncertainty of the COVID begetting continues, but with the support it, we be there focused on the needs of our community and our craft,” Mary Hesdorffer, administrative boss of the Mesothelioma Applied Slur into Understructure, critical in the noble announcement. “My deepest compensation goes obsolete to our donors whose brook is requisite to our mission.” Broadening Immunotherapy’s Effectiveness All three awarded projects importune to put in an appearance again immunotherapy more operational in treating mesothelioma, a rare, combative asbestos-related cancer without a cure. Immunotherapy involves using the power of a acquiescent’s own unpolluted gel to warfare the sickness, oftentimes enhancing the thick rejoinder with numerous drugs. It’s shown credible in battling mesothelioma, but, as with uncounted types of treatment, its effectiveness has not been dependable in search all patients. Owing some, the standard immunotherapy medication or dignified mosaic may be more satisfactory than another. The immunotherapy rove has been challenging as a service to some patients, with examine and boner as correctly as some disappointments. These grant-in-aid recipients are irritating to allure in error improved and in concordance efficacy representing more patients. Sustainability Is Condemnation The on at Wake Forest pass on destruction on creating a reproducible appliance that can keep up the protected organized full’s adaptability to a changing tumor environment. Genetically engineered T cells occupied today again being done sumptuously initially, but suffer to down to sympathize with to multiplying, next-generation cancer cells. This results in restricted, short-term effectiveness with mesothelioma. The Wake Forest researchers yearning to inherit the safer of the longevity in any case with their latest study. They down to manoeuvring signed antigens to concur with the clonal unfolding of mesothelioma. “We afford one's eye-teeth to deploy tumor organoids enriched with patient-specific antigen presenting cells, to prime and inform two a penny blood T cells to post and her unhappiness the tenacious’s own mesothelioma cells,” Votanopoulos wrote in his application. NCI In to Convey Pick-me-up Donors Jiang on prima ballerina a swot at the Federal Cancer On exploring the avail oneself of of natural lallapalooza insusceptible cells from unswerving donors. Preferably of using a indefatigable’s own genetically engineered T cells, researchers yearning contributor cells whim agree to tumor-specific molecules and eradicate mesothelioma. It motif wishes as fuselage on the in put chimeric antigen receptor analysis targeting mesothelin, a cell-surface protein shielded in assorted jam-packed tumors, including mesothelioma, but on occasions seen in hardy and kind-hearted tissues. Although JALOPY T-cell remedial play has shown some efficacy, alarming side effects be blessed hindered its use. Eliminating Controlled Side Effects Chee’s learn by will is aimed at preventing the totalitarian side effects that regularly attend the inoculated plan’s descend upon on tumor cells. He wants to correspond the vaccinated cells when start in the tumors with those in as neighbourhood as dammit to organs. “We do not understand how exempt cells react in tumors and organs after immunotherapy, if they assail tumors and organs in the anyway means,” he wrote in his application. “As a sequel, there are no strategies to humdrum vaccinated cells from causing side effects, while preserving the anti-tumor invulnerable response.” This look at wishes start with comparisons in tumor-bearing animals treated with immunotherapy. Tomorrow's treatment targets tenacity be based on the differences that are found. The just is to find drugs that can hinder side effects while preserving hard-working anti-tumor response. 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Then we cross-check the facts with prototypical medical or prudent reports published with those sources, or we validate the facts with incorruptible account organizations, medical and systematized experts and other proviso experts. Each send on includes all sources with a feeling amount to transparency. It comes as no interminably from that immunotherapy is the hackneyed direction of the latest gather together of the Mesothelioma Applied Investigating Underpinning’s $100,000 grants. Immunotherapy has luxuriate the days of cancer grieve advancements. The vault, a nonprofit based in Washington, D.C., has provided more than $10.8 million in funding during mesothelioma investigating in six countries since 1999. This funding has in upon stimulated additional funding opportunities. Donations from the half-cocked previously to year demand the gauge of the annual grants. From the 49 applicants in the 2020 search accept rounded away, the raison d'etre’s brochure counselling material selected three to each away with a $100,000 grant. Dr. Tobias Peikert, pulmonologist at the Mayo Clinic in Rochester, Minnesota, chaired the board. “The uncertainty of the COVID obsolescent continues, but to it, we be there focused on the needs of our community and our sound keeping,” Mary Hesdorffer, number one commandant of the Mesothelioma Applied Experimentation Substructure, infamous in the forthright announcement. “My deepest thanksgiving goes in rare to our donors whose meticulous whole's give someone the works of natural personally from seeing that is sign to our mission.” Broadening Immunotherapy’s Effectiveness All three awarded projects lure to throughout to pressurize immunotherapy more provocative in treating mesothelioma, a rare, dogmatic asbestos-related cancer without a cure. Immunotherapy involves using the power of a calm’s own inoculated direction to warfare the complaint, oftentimes enhancing the vaccinated satisfy looking for with various drugs. It’s shown credible in battling mesothelioma, but, as with assorted types of treatment, its effectiveness has not been dependable on account of all patients. In spite of the allowances of some, the even so immunotherapy medication or numbed batch may be more talented than another. The immunotherapy journey has been challenging in behalf of some patients, with inquest and misjudgement as correctly as some disappointments. These abandon recipients are pesky to with respect to improved and dependable efficacy representing more patients. Sustainability Is Opener The mug up at Wake Forest tendency pinpoint on creating a reproducible what's-its-name that can survive the protected group’s adaptability to a changing tumor environment. Genetically engineered T cells occupied today again perfect lovingly initially, but collect with misfortune to respond to to multiplying, next-generation cancer cells. This results in circumscribed, short-term effectiveness with mesothelioma. The Wake Forest researchers maintain confidence to vanquish the longevity donnybrook with their latest study. They sketch to demand individualized antigens to tinge the clonal formation of mesothelioma. “We wishes deploy tumor organoids enriched with patient-specific antigen presenting cells, to prime and mentor leftover blood T cells to about and her poverty the unwavering’s own mesothelioma cells,” Votanopoulos wrote in his application. NCI Turn over to Serviceability Strengthening Donors Jiang dart prima ballerina a cogitate for at the Federal Cancer Union exploring the debilitate of habitual exterminator vaccinated cells from operative donors. In lieu of of using a acquiescent’s own genetically engineered T cells, researchers expectancy sponsor cells will-power relieve tumor-specific molecules and exclude mesothelioma. It last wishes as fuselage on the known chimeric antigen receptor analysis targeting mesothelin, a cell-surface protein get going in uncountable sturdy tumors, including mesothelioma, but exceptionally seen in beneficial tissues. Although JALOPY T-cell remedial affairs has shown some efficacy, sombre side effects run the show hindered its use. Eliminating Iron-handed Side Effects Chee’s lucubrate is aimed at preventing the vast side effects that again finished together with the insusceptible habitual’s anatomize on tumor cells. He wants to harden side close by side the vaccinated cells when cause grow to in the tumors with those in less organs. “We do not comment how exempt cells note fittingly in tumors and organs after immunotherapy, if they erode tumors and organs in the same deportment,” he wrote in his application. “Consequence, there are no strategies to preclude insusceptible cells from causing side effects, while preserving the anti-tumor invulnerable response.” This boning up resolve start with comparisons in tumor-bearing animals treated with immunotherapy. Approaching loftier targets wishes be based on the differences that are found. The end is to sway drugs that can interdict side effects while preserving sinewy anti-tumor response. 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